US researchers have used NMR spectroscopy in a study of the activity of the tumour suppressor protein, p53. Their work reveals the mechanism by which p53 triggers programmed cell death (apoptosis) and may have implications for understanding the development of various forms of cancer and perhaps lead to new drug discoveries.
Harnessing insulation: Magnetic clue
Harnessing insulation: Magnetic clue
http://www.spectroscopynow.com/common/images/thumbnails/14cb69ea9eb.jpgA subatomic magnetic phenomenon predicted more than sixty years ago has been measured for the first time. The demonstration of van Vleck magnetism could open the door to harnessing topological insulators - hybrid materials that are both conducting and insulating - and may well lead to new approaches to quantum computing, spintronics applications, and much-improved semiconductors.
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04-15-2015 04:40 PM
St. Jude analysis reveals how protein p53 triggers cancer cells to commit suicide - News-Medical.net
St. Jude analysis reveals how protein p53 triggers cancer cells to commit suicide - News-Medical.net
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St. Jude analysis reveals how protein p53 triggers cancer cells to commit suicide
News-Medical.net
In their studies, the researchers used a structural analysis technique called NMR spectroscopy to map the 3-D structure of p53 binding to BCL-xL. Their experiments also revealed in detail how one region of the p53 protein, called the DNA-binding domain ...
Detailed Studies Reveal how key Cancer-Fighting Protein is Held in CheckPR Web (press release)
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05-16-2014 07:46 AM
Alzheimer's disease: NMR pinpoints genetic clue
Alzheimer's disease: NMR pinpoints genetic clue
http://www.spectroscopynow.com/common/images/thumbnails/1438cadfde3.jpgResearchers have turned to solution NMR spectroscopy to help them characterise the structure and dynamics of the transmembrane portion of the protein amyloid precursor protein, APP, of which there are two genetic variants linked to familial, or hereditary Alzheimer's disease.
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01-15-2014 05:05 AM
[NMR paper] Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines.
Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines.
Biochim Biophys Acta. 2013 Jan 26;
Authors: Rose HM, Stuiver M, Thongwichian R, Theillet FX, Feller SM, Selenko P
Abstract
We comparatively analyzed the basal activity...
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02-03-2013 10:19 AM
Spliced: NMR reveals structural clue to transcription
Spliced: NMR reveals structural clue to transcription
Biomolecular NMR experts in Germany have discovered how the U2AF protein facilitates the process of splicing used by cells to make the correct template for RNA transcription and the subsequent expression of proteins.
Source: Spectroscopynow.com
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08-01-2011 12:07 AM
NMR solution structure of human VRK1 reveals the C-terminal tail essential for structural stability and autocatalytic activity.
NMR solution structure of human VRK1 reveals the C-terminal tail essential for structural stability and autocatalytic activity.
NMR solution structure of human VRK1 reveals the C-terminal tail essential for structural stability and autocatalytic activity.
J Biol Chem. 2011 May 3;
Authors: Shin J, Chakraborty G, Bharatham N, Kang C, Tochio N, Koshiba S, Kigawa T, Kim W, Kim KT, Yoon HS
Vaccinia-related kinase 1 (VRK1) is one of the mitotic kinases which play important roles in cell cycle, nuclear condensation and transcription regulation. Kinase...
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05-06-2011 12:02 PM
NMR reveals novel mechanisms of protein activity regulation.
NMR reveals novel mechanisms of protein activity regulation.
NMR reveals novel mechanisms of protein activity regulation.
Protein Sci. 2011 Mar 14;
Authors: Kalodimos CG
NMR spectroscopy is one of the most powerful tools for the characterization of biomolecular systems. A unique aspect of NMR is its capacity to provide an integrated insight into both the structure and intrinsic dynamics of biomolecules. In addition, NMR can provide site-resolved information about the conformation entropy of binding, as well as about energetically excited...
NMR reveals cancer clue: p53 activity
US researchers have used NMR spectroscopy in a study of the activity of the tumour suppressor protein, p53. Their work reveals the mechanism by which p53 triggers programmed cell death (apoptosis) and may have implications for understanding the development of various forms of cancer and perhaps lead to new drug discoveries. 
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