Proton nuclear magnetic resonance (NMR) spectroscopy has been used in research that reveals the first definitive evidence for a new type of molecular structure with a bond between two negatively charged moieties.
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GSK, Avalon expand biotech deal
The San Diego Union-Tribune
The SBP researchers used multiple methods to find and verify this particular protein-protein interaction, including molecular modeling, biophysics, nuclear magnetic resonance spectroscopy and synthetic chemistry to slowly design a molecule that blocks ...
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nmrlearner
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11-09-2015 05:03 PM
[NMR paper] Peak picking NMR spectral data using non-negative matrix factorization.
Peak picking NMR spectral data using non-negative matrix factorization.
Peak picking NMR spectral data using non-negative matrix factorization.
BMC Bioinformatics. 2014 Feb 11;15(1):46
Authors: Tikole S, Jaravine V, Rogov V, Dötsch V, Güntert P
Abstract
BACKGROUND: Simple peak-picking algorithms, such as those based on lineshape fitting, perform well when peaks are completely resolved in multidimensional NMR spectra, but often produce wrong intensities and frequencies for overlapping peak clusters. For example, NOESY-type spectra...
nmrlearner
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02-12-2014 11:48 AM
[Question from NMRWiki Q&A forum] 31P signal at negative 74 ppm
31P signal at negative 74 ppm
Hello All
Does anyone have any ideas on what might give a phosphorus signal at negative 74 ppm (cf phosphoric acid)? There's a very small signal in many of my 31P spectra at -74 ppm. It's not a spectrometer artefact and it it present in samples prepared by different people on- and off-site using different tubes and different sources of solvents. The samples are chemically variable too, alkyl/aryl-phosphines in organic solvents, phosphates in water but there's this little curiousity at -74 ppm.
Thank-you.
nmrlearner
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11-12-2013 03:52 PM
[Question from NMRWiki Q&A forum] why we are seeing negative PREs in paramagnetic relaxation enhancement experiment?
why we are seeing negative PREs in paramagnetic relaxation enhancement experiment?
Hi NMR Wiki users,
I'm using two point method(Marius Clore and Junji Iwahara methods) to measure the PREs, but in my experiment I observed so many negative PREs. Is there any chance to use these negative PREs data in structure calculation.How can I get all positive PREs,otherwise I lose half of the data in my calculations.
Check if somebody has answered this question on NMRWiki QA forum
nmrlearner
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12-11-2012 07:30 PM
[Question from NMRWiki Q&A forum] negative NMR peaks
negative NMR peaks
I am very new to NMR and have little experience of it. However I am trying to use it to determine the composition of a mixture. A spectra which I have just obtained contains negative peaks which are giving me incorrect inegrals.
What would cause this? and is there any way to correct it? I can't find much in literature regarding this.
Thanks for your help
Dean
nmrlearner
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06-21-2011 03:40 PM
[NMR paper] Negative entropy of halothane binding to protein: 19F-NMR with a novel cell.
Negative entropy of halothane binding to protein: 19F-NMR with a novel cell.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Negative entropy of halothane binding to protein: 19F-NMR with a novel cell.
Biochim Biophys Acta. 1997 Mar 15;1334(2-3):117-22
Authors: Yoshida T, Tanaka M, Mori Y, Ueda I
An obvious difficulty of the study of binding of volatile anesthetics to proteins is to prevent loss of the ligand during the procedure. A novel NMR tube was designed that...
nmrlearner
Journal club
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08-22-2010 03:31 PM
[NMR paper] Negative entropy of halothane binding to protein: 19F-NMR with a novel cell.
Negative entropy of halothane binding to protein: 19F-NMR with a novel cell.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Negative entropy of halothane binding to protein: 19F-NMR with a novel cell.
Biochim Biophys Acta. 1997 Mar 15;1334(2-3):117-22
Authors: Yoshida T, Tanaka M, Mori Y, Ueda I
An obvious difficulty of the study of binding of volatile anesthetics to proteins is to prevent loss of the ligand during the procedure. A novel NMR tube was designed that...
Negative union: NMR on ions together
Proton nuclear magnetic resonance (NMR) spectroscopy has been used in research that reveals the first definitive evidence for a new type of molecular structure with a bond between two negatively charged moieties.
Linear Mode
