Nuclear magnetic resonance (NMR) spectroscopy technology has been used to investigate how two proteins important in a hereditary form of motor neurone disease, Kap-?2 importin and the FUS protein, bind to each other. The research could ultimately lead the way to a better understanding of this neurodegenerative disease.
Motor neurone link: NMR investigates proteins - spectroscopyNOW.com
Motor neurone link: NMR investigates proteins - spectroscopyNOW.com
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Motor neurone link: NMR investigates proteins
spectroscopyNOW.com
Nuclear magnetic resonance (NMR) spectroscopy technology has been used to investigate how two proteins important in a hereditary form of motor neurone disease (MND), Kapβ2 importin and the FUS protein, bind to each other. The research could ...
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07-06-2018 09:40 AM
Segmental isotope labelling and solid-state NMR of a 12â??Ã?â??59Â*kDa motor protein: identification of structural variability
Segmental isotope labelling and solid-state NMR of a 12â??Ã?â??59Â*kDa motor protein: identification of structural variability
Abstract
Segmental isotope labelling enables the NMR study of an individual domain within a multidomain protein, but still in the context of the entire full-length protein. Compared to the fully labelled protein, spectral overlap can be greatly reduced. We here describe segmental labelling of the (double-) hexameric DnaB helicase from Helicobacter pylori using a ligation approach. Solid-state spectra demonstrate that the...
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06-12-2018 08:40 AM
[NMR paper] Protein-nucleotide contacts in motor proteins detected by DNP-enhanced solid-state NMR.
Protein-nucleotide contacts in motor proteins detected by DNP-enhanced solid-state NMR.
Related Articles Protein-nucleotide contacts in motor proteins detected by DNP-enhanced solid-state NMR.
J Biomol NMR. 2017 Nov 08;:
Authors: Wiegand T, Liao WC, Ong TC, Däpp A, Cadalbert R, Copéret C, Böckmann A, Meier BH
Abstract
DNP (dynamic nuclear polarization)-enhanced solid-state NMR is employed to directly detect protein-DNA and protein-ATP interactions and identify the residue type establishing the intermolecular contacts. While...
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11-10-2017 05:01 PM
Proteinâ??nucleotide contacts in motor proteins detected by DNP-enhanced solid-state NMR
Proteinâ??nucleotide contacts in motor proteins detected by DNP-enhanced solid-state NMR
Abstract
DNP (dynamic nuclear polarization)-enhanced solid-state NMR is employed to directly detect proteinâ??DNA and proteinâ??ATP interactions and identify the residue type establishing the intermolecular contacts. While conventional solid-state NMR can detect proteinâ??DNA interactions in large oligomeric protein assemblies in favorable cases, it typically suffers from low signal-to-noise ratios. We show here, for the oligomeric DnaB helicase from...
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11-09-2017 08:55 AM
[NMR paper] NMR Metabolomics Investigates the Influence of Flavonoid-Enriched Rations on Chicken Plasma.
NMR Metabolomics Investigates the Influence of Flavonoid-Enriched Rations on Chicken Plasma.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ingentaconnect.com-images-ingenta-connect.png Related Articles NMR Metabolomics Investigates the Influence of Flavonoid-Enriched Rations on Chicken Plasma.
J AOAC Int. 2017 Mar 01;100(2):315-322
Authors: Fotakis C, Lantzouraki DZ, Goliomytis M, Simitzis PE, Charismiadou M, Deligeorgis SG, Zoumpoulakis P
Abstract
The use of flavonoids as dietary supplements is...
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06-07-2017 01:35 PM
Public Release: 14-Sep-2015 Swinging on 'monkey bars': Motor proteins caught ... - EurekAlert (press release)
Public Release: 14-Sep-2015 Swinging on 'monkey bars': Motor proteins caught ... - EurekAlert (press release)
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Public Release: 14-Sep-2015 Swinging on 'monkey bars': Motor proteins caught ...
EurekAlert (press release)
Researchers at the University of Leeds and in Japan used electron microscopes to capture images of the largest type of motor protein, called dynein, during the act of stepping along its molecular...
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09-14-2015 10:42 PM
[NMR paper] MOTOR: Model assisted software for NMR structure determination.
MOTOR: Model assisted software for NMR structure determination.
Related Articles MOTOR: Model assisted software for NMR structure determination.
Proteins. 2013 Jul 15;
Authors: Schieborr U, Sreeramulu S, Elshorst B, Maurer M, Saxena K, Stehle T, Kudlinzki D, Gande SL, Schwalbe H
Abstract
Eukaryotic proteins with important biological function can be partially unstructured, conformational flexible or heterogenic. Crystallization trials often fail for such proteins. In NMR spectroscopy, parts of the polypeptide chain undergoing dynamics in...
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07-16-2013 09:04 PM
A link to MolMol2K for Linux
<a href=http://pjf.net/science/molmol.html>MolMol binaries for Linux distribution Red Hat 7.3 and 9 built by Patrik Finerty</a>
Motor neurone link: NMR investigates proteins
Nuclear magnetic resonance (NMR) spectroscopy technology has been used to investigate how two proteins important in a hereditary form of motor neurone disease, Kap-?2 importin and the FUS protein, bind to each other. The research could ultimately lead the way to a better understanding of this neurodegenerative disease.
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