Unexpected systematic signals in the proton NMR spectra of an iron catalyst have serendipitously led to a new way to radiolabel compounds and track how drugs are metabolized in the body.
Bolus tracking for improved metabolic imaging of hyperpolarised compounds
From The DNP-NMR Blog:
Bolus tracking for improved metabolic imaging of hyperpolarised compounds
Durst, M., et al., Bolus tracking for improved metabolic imaging of hyperpolarised compounds. J. Magn. Reson., 2014. 243(0): p. 40-46.
http://dx.doi.org/10.1016/j.jmr.2014.02.011
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06-14-2014 12:53 AM
New NMR cancer model: Tracking progress
New NMR cancer model: Tracking progress
http://www.spectroscopynow.com/common/images/thumbnails/141a639aeec.jpgA new modelling technique for real-time tracking of metabolic reactions in tumours has been developed by UK researchers. The system based on a simplified computer model of nuclear magnetic resonance spectra could allow oncologists to assess how well their prescribed treatment, whether chemotherapy, radiotherapy or an immunological treatment is progressing without surgical intervention nor the need for regular biopsies.
Read the rest at Spectroscopynow.com
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10-15-2013 09:40 AM
[NMR paper] Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy.
Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy.
Mech Ageing Dev. 2013 Mar;134(3-4):130-8
Authors: Gey C, Seeger K
Abstract
Cellular senescence is of growing interest due to its role in tumour suppression and its contribution to organismic ageing. This cellular state can be...
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Journal club
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10-01-2013 11:15 PM
Colon cancer calculated: Metabolic profiling
Colon cancer calculated: Metabolic profiling
http://www.spectroscopynow.com/common/images/thumbnails/14077d20717.jpgNuclear magnetic resonance (NMR) spectroscopy can be used to obtain a metabolic fingerprint of cancer of the bowel and so determine how far advanced the disease is, according to UK researchers.
Read the rest at Spectroscopynow.com
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08-15-2013 07:22 AM
NMR metabolic and physiological markers of therapeutic response.
NMR metabolic and physiological markers of therapeutic response.
NMR metabolic and physiological markers of therapeutic response.
Adv Exp Med Biol. 2011;701:129-35
Authors: Lee SC, Poptani H, Delikatny EJ, Pickup S, Nelson DS, Schuster SJ, Nasta SD, Svoboda J, Goldstein SC, Wallace SG, Loevner LA, Mellon EA, Reddy R, Glickson JD
Identification of reliable metabolic and physiological NMR detectable markers for prediction and early detection of therapeutic response is essential to enabling NMR guided individualized therapy for cancer. Because...
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Journal club
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08-17-2011 01:33 PM
Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
J Proteome Res. 2010 Dec 3;9(12):6729-39
Authors: Szeto SS, Reinke SN, Sykes BD, Lemire BD
Metabolomics is a powerful method of examining the intricate connections between mutations, metabolism, and disease. Metabolic...
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Journal club
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05-25-2011 07:01 PM
spectroscopy to fingerprint a person's metabolic phenotype
spectroscopy to fingerprint a person's metabolic phenotype
Now, NMR spectroscopy has revealed that an "omic" other than genomic could provide a unique view of each of the 6.7 billion people on earth - their metabonomic fingerprint.
More...
Metabolic tracking: NMR and radiolabels
Unexpected systematic signals in the proton NMR spectra of an iron catalyst have serendipitously led to a new way to radiolabel compounds and track how drugs are metabolized in the body.
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