Human insulin preparations were used to demonstrate that the transverse relaxation rate of water protons can serve as a sensitive and reliable indicator to detect and quantify both visible and sub-visible protein aggregates.
Journal Highlight: Metabolic abnormalities of gastrointestinal mucosa in celiac disease: An in vitro proton NMR spectroscopy study
Journal Highlight: Metabolic abnormalities of gastrointestinal mucosa in celiac disease: An in vitro proton NMR spectroscopy study
http://www.spectroscopynow.com/common/images/thumbnails/150ae3edbc9.jpgProton NMR spectroscopy has been used to investigate the differences in metabolic profile of duodenal mucosal biopsies of patients with celiac disease and controls to find out the biomarker's of villous atrophy.
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11-01-2015 01:52 PM
[NMR paper] Water Proton NMR for In Situ Detection of Insulin Aggregates.
Water Proton NMR for In Situ Detection of Insulin Aggregates.
Related Articles Water Proton NMR for In Situ Detection of Insulin Aggregates.
J Pharm Sci. 2015 Sep 7;
Authors: Taraban MB, Truong HC, Feng Y, Jouravleva EV, Anisimov MA, Yu YB
Abstract
The need for quality control during the manufacturing and distribution of biopharmaceuticals is becoming increasingly necessary. At present, detecting drug degradation through the monitoring of active factor aggregation is accomplished through "invasive" techniques, such as...
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09-08-2015 11:26 PM
Journal Highlight: Environmental NMR – the early years
Journal Highlight: Environmental NMR – the early years
http://www.spectroscopynow.com/common/images/thumbnails/14f6f8f5423.jpgA personal viewpoint of the development of environmental NMR spectroscopy is presented from its beginnings when it was applied to the analysis of soil humic acids.
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Journal Highlight: On the tuning of high-resolution NMR probes
Journal Highlight: On the tuning of high-resolution NMR probes
http://www.spectroscopynow.com/common/images/thumbnails/14a0562f4b6.jpgThree optimum conditions for the tuning of NMR probes are compared: the conventional tuning optimum, the spin noise tuning optimum and the newly introduced frequency shift tuning optimum.
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12-01-2014 12:17 PM
Journal Highlight: Quantitative 2D liquid-state NMR
Journal Highlight: Quantitative 2D liquid-state NMR
http://www.spectroscopynow.com/common/images/thumbnails/1465cafc4c8.jpgThis review aims at presenting recent efforts to reach a high trueness and precision in quantitative measurements of liquids by 2D NMR.
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06-02-2014 10:02 PM
Journal Highlight: 3He NMR: from free gas to its encapsulation in fullerene
Journal Highlight: 3He NMR: from free gas to its encapsulation in fullerene
http://www.spectroscopynow.com/common/images/thumbnails/1403959935b.jpgThe 3He nuclear magnetic shieldings were calculated for single helium atom, its dimer, simple models of fullerene cages (He@Cn), and single wall carbon nanotubes.
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08-05-2013 09:06 AM
NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel
NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel
Fanghao Hu, Klaus Schmidt-Rohr and Mei Hong
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja2081185/aop/images/medium/ja-2011-081185_0008.gif
Journal of the American Chemical Society
DOI: 10.1021/ja2081185
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/C3pPoB5_PR8
Journal Highlight: Water proton NMR for in situ detection of insulin aggregates
Human insulin preparations were used to demonstrate that the transverse relaxation rate of water protons can serve as a sensitive and reliable indicator to detect and quantify both visible and sub-visible protein aggregates.
Linear Mode
