Methylene blue is well known as a redox indicator in chemical laboratories, but it may also have a role to play in warding off the symptoms of Alzheimer's disease, according to a new study, or perhaps lead to novel drugs for the disorder based on its chemical structure and properties. Mechanistic details of the compound's putative mode of action are revealed in the journal Angewandte Chemie by researchers using nuclear magnetic resonance (NMR) and spectroscopy and other approaches.
Alzheimer's analysed: New clues in brain disease
Alzheimer's analysed: New clues in brain disease
http://www.spectroscopynow.com/common/images/thumbnails/13af4d7f690.jpgRecent studies have added weight to the idea that amyloid-beta is a causative agent in Alzheimer's disease rather than the plaques formed from these chunks of misfolded peptide that deposit in the diseased brain. Now, European researchers have used REAPDOR solid-state NMR spectroscopy to analyse the hydrogen bonds in the tiny fibrils of amyloid-beta peptide, offering another perspective on this neurodegenerative disorder.
Source: Spectroscopynow.com
nmrlearner
General
0
02-03-2013 08:49 AM
Misbehaving Protein May Provide Clue to Alzheimer's Drug - Bloomberg
<img alt="" height="1" width="1" />
Misbehaving Protein May Provide Clue to Alzheimer's Drug
Bloomberg
Nuclear Imaging Tools Researchers used nuclear magnetic resonance imaging and computer modeling to see how proteins assemble themselves. Many of the intermediate states of folding last a millisecond or less, said Lewis Kay, a study author and a ...
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Misbehaving Protein May Provide Clue to Alzheimer's Drug - Bloomberg
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nmrlearner
Online News
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04-19-2012 07:35 PM
[Question from NMRWiki Q&A forum] Varian Gemini 300 Transmitter Board Indicator Lights
Varian Gemini 300 Transmitter Board Indicator Lights
I am having problems with a Varian Gemini 300 console. During the troubleshooting process, I noticed that the number of green lights activated on all of the transmitter boards has changed. In the schematic manual, these lights are labeled as XMTR, LOCK, OFF, and L0. However, I cannot find any more information as to what exactly these lights indicate. Can anyone help?
Thanks in advance.
Check if somebody has answered this question on NMRWiki QA forum
nmrlearner
News from other NMR forums
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07-22-2011 10:39 PM
[NMR analysis blog] Micropost: Pulse Sequence Blues!
Micropost: Pulse Sequence Blues!
Now that ENC is practically around the corner, here is a link that shows how far this conference encourages the participants’ creativity:
Pulse Sequence Blues!
NMR can also be fun :-)
https://blogger.googleusercontent.com/tracker/6953549091784501422-8328472542836523761?l=nmr-analysis.blogspot.com
nmrlearner
News from NMR blogs
0
02-23-2011 11:21 PM
[NMR analysis blog] Micropost: Pulse Sequence Blues!
Micropost: Pulse Sequence Blues!
Now that ENC is practically around the corner, here is a link that shows how far this conference encourages the participants’ creativity:
Pulse Sequence Blues!
NMR can also be fun :-)
https://blogger.googleusercontent.com/tracker/6953549091784501422-8328472542836523761?l=nmr-analysis.blogspot.com
nmrlearner
News from NMR blogs
0
02-23-2011 11:18 PM
[NMR paper] Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloi
Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR.
Related Articles Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR.
Protein Expr Purif. 2005 Jul;42(1):200-10
Authors: Sharpe S, Yau WM, Tycko R
Fibrillar protein aggregates contribute to the pathology of a number of disease states. To facilitate structural studies of these amyloid fibrils by solid-state NMR, efficient methods for the production of milligram...
nmrlearner
Journal club
0
11-24-2010 11:14 PM
[Stan NMR blog] Old Swan's eDISPA blues
Old Swan's eDISPA blues
Debate about the efficiency of an automatic phase correction algorithm.
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nmrlearner
News from NMR blogs
0
08-21-2010 05:42 PM
Copper, on the beat with NMR
Copper, on the beat with NMR
The first NMR spectroscopy study of the copper site in an important blue metalloprotein, azurin, has been undertaken. Copper mediates many biochemical redox reactions and azurin plays an important role in catalysing electron transfer in cellular reactions.
Source: Spectroscopynow.com
Indicator: Beat the Alzheimer's blues
Methylene blue is well known as a redox indicator in chemical laboratories, but it may also have a role to play in warding off the symptoms of Alzheimer's disease, according to a new study, or perhaps lead to novel drugs for the disorder based on its chemical structure and properties. Mechanistic details of the compound's putative mode of action are revealed in the journal Angewandte Chemie by researchers using nuclear magnetic resonance (NMR) and spectroscopy and other approaches.
Linear Mode
