NMR spectroscopy has been used to home in on a vulnerable point in the HIV viral machinery, the envelope protein, gp41 membrane proximal external region. The research steals a march on other studies for which the protein is inaccessible, potentially leading the way to a vaccine or new targets for antiviral drugs against the disease.
No more falling foul: NMR reveals poultry target
No more falling foul: NMR reveals poultry target
http://www.spectroscopynow.com/common/images/thumbnails/1429e8e6e29.jpgNMR spectroscopy has defined the substance responsible for the protective effect of the microbe Lactobacillus johnsonii, which is known to inhibit Clostridium perfringens infection the in gut of poultry. The finding could point the way to a new veterinary drug for preventing necrotic enteritis in poultry.
Read the rest at Spectroscopynow.com
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01-14-2014 03:20 PM
No more falling foul: NMR reveals poultry target
No more falling foul: NMR reveals poultry target
http://www.spectroscopynow.com/common/images/thumbnails/1429e8e6e29.jpgNuclear magnetic resonance (NMR) spectroscopy has defined the substance responsible for the protective effect of the microbe Lactobacillus johnsonii, which is known to inhibit Clostridium perfringens infection the in gut of poultry. The finding could point the way to a new veterinary drug for preventing necrotic enteritis in poultry.
Read the rest at Spectroscopynow.com
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12-01-2013 07:03 AM
LipoScience Price Target Cut to $10.00 (LPDX) - Zolmax
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LipoScience Price Target Cut to $10.00 (LPDX)
Zolmax
The Company's first diagnostic test, the nuclear magnetic resonance (NASDAQ:LPDX) LipoProfile test, directly measures the number of low density lipoprotein (LDL), particles in a blood sample and provides physicians and their patients with actionable ...
LipoScience Price Target Cut to $10.00 (LPDX) - Zolmax
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08-08-2013 03:46 PM
3D target: Membrane protein structure - spectroscopyNOW.com
3D target: Membrane protein structure - spectroscopyNOW.com
http://www.bionmr.com//nt1.ggpht.com/news/tbn/rfP-uJkLWTqT-M/6.jpg
spectroscopyNOW.com
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3D target: Membrane protein structure
spectroscopyNOW.com
The three-dimensional structure of a complete, unmodified G-protein-coupled receptor in its native, membrane environment under physiological conditions has been obtained NMR spectroscopy. In October, chemists the world over were stunned by the ...
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11-01-2012 10:18 AM
[NMR paper] Application of NMR SHAPES screening to an RNA target.
Application of NMR SHAPES screening to an RNA target.
Related Articles Application of NMR SHAPES screening to an RNA target.
J Am Chem Soc. 2003 Dec 24;125(51):15724-5
Authors: Johnson EC, Feher VA, Peng JW, Moore JM, Williamson JR
Several NMR screening techniques have been developed in recent years to aid in the identification of lead drug compounds. These NMR methods have traditionally been used for protein targets, and here we examine their applicability for an RNA target. We used the SHAPES compound library to test three different NMR...
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11-24-2010 09:16 PM
NMR Studies of Translocation of the Zif268 Protein between Its Target DNA Sites
NMR Studies of Translocation of the Zif268 Protein between Its Target DNA Sites
http://pubs.acs.org//appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/bi100962h/aop/images/medium/bi-2010-00962h_0005.gifBiochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable).
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08-31-2010 10:50 PM
[NMR paper] Limits of NMR structure determination using variable target function calculations: ri
Limits of NMR structure determination using variable target function calculations: ribonuclease T1, a case study.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Limits of NMR structure determination using variable target function calculations: ribonuclease T1, a case study.
J Mol Biol. 1997 Feb 21;266(2):400-23
Authors: Pfeiffer S, Karimi-Nejad Y, Rüterjans H
Limits of NMR structure determination using multidimensional NMR spectroscopy, variable target function...
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08-22-2010 03:03 PM
NMR studies of translocation of the Zif268 protein between its target DNA sites.
NMR studies of translocation of the Zif268 protein between its target DNA sites.
Related Articles NMR studies of translocation of the Zif268 protein between its target DNA sites.
Biochemistry. 2010 Aug 19;
Authors: Takayama Y, Sahu D, Iwahara J
Zif268 is a zinc-finger protein containing three Cys2-His2-type zinc-finger domains that bind the target DNA sequence GCGTGGGCG in a cooperative manner. In this work, we characterized translocation of the Zif268 protein between its target DNA sites using NMR spectroscopy. The residual dipolar coupling...
HIV target: NMR revelations
NMR spectroscopy has been used to home in on a vulnerable point in the HIV viral machinery, the envelope protein, gp41 membrane proximal external region. The research steals a march on other studies for which the protein is inaccessible, potentially leading the way to a vaccine or new targets for antiviral drugs against the disease.
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