Various techniques have been used in studies that show how linking therapeutically active molecules to specific antibodies can help them target disease sites, specifically in cancer, and so minimize side effects.
CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis
CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis
Abstract
NMR spectroscopy is an indispensably powerful technique for the analysis of biomolecules under ambient conditions, both for structural- and functional studies. However, in practice the complexity of the technique has often frustrated its application by non-specialists. In this paper, we present CcpNmr version-3, the latest software release from the Collaborative Computational Project for NMR, for all aspects of NMR data analysis, including liquid- and solid-state NMR data....
nmrlearner
Journal club
0
09-23-2016 12:55 PM
Flexible Meccano
Flexible Meccano
Software package for NMR studies of flexibly disordered proteins
More...
[NMR paper] Enhancement of transglutaminase activity by NMR identification of its flexible residu
Enhancement of transglutaminase activity by NMR identification of its flexible residues affecting the active site.
Related Articles Enhancement of transglutaminase activity by NMR identification of its flexible residues affecting the active site.
FEBS Lett. 2002 Apr 24;517(1-3):175-9
Authors: Shimba N, Shinohara M, Yokoyama K, Kashiwagi T, Ishikawa K, Ejima D, Suzuki E
Incorporation of inter- or intramolecular covalent cross-links into food proteins with microbial transglutaminase (MTG) improves the physical and textural properties of many...
nmrlearner
Journal club
0
11-24-2010 08:49 PM
[NMR paper] NMR experiments for resonance assignments of 13C, 15N doubly-labeled flexible polypep
NMR experiments for resonance assignments of 13C, 15N doubly-labeled flexible polypeptides: application to the human prion protein hPrP(23-230).
Related Articles NMR experiments for resonance assignments of 13C, 15N doubly-labeled flexible polypeptides: application to the human prion protein hPrP(23-230).
J Biomol NMR. 2000 Feb;16(2):127-38
Authors: Liu A, Riek R, Wider G, von Schroetter C, Zahn R, Wüthrich K
A combination of three heteronuclear three-dimensional NMR experiments tailored for sequential resonance assignments in uniformly 15N,...
nmrlearner
Journal club
0
11-18-2010 09:15 PM
[NMR paper] Simulated annealing with restrained molecular dynamics using a flexible restraint pot
Simulated annealing with restrained molecular dynamics using a flexible restraint potential: theory and evaluation with simulated NMR constraints.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_FREE_120x27.gif http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Simulated annealing with restrained molecular dynamics using a flexible restraint potential: theory and evaluation with simulated NMR constraints.
...
nmrlearner
Journal club
0
08-22-2010 02:27 PM
[NMR paper] 1H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 1
1H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 18 amino acids.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 1H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 18 amino acids.
FEBS Lett. 1995 Aug 7;369(2-3):305-10
Authors: Carver JA, Esposito G, Schwedersky G, Gaestel M
The small heat-shock proteins (Hsps) exist as large aggregates and function by interacting and stabilising non-native proteins in...