Nuclear magnetic resonance (NMR) spectroscopy can be used to quickly identify a biomarker for the presence of gamma-hydroxybutyric acid (GHB, the so-called "date rape" drug) in a biological sample from a putative victim of crime. Details are reported in the American Chemical Society's journal Analytical Chemistry.
[NMR paper] NMR-based metabolomics reveals the metabolite profiles of Vibrio parahaemolyticus under ferric iron stimulation.
NMR-based metabolomics reveals the metabolite profiles of Vibrio parahaemolyticus under ferric iron stimulation.
Related Articles NMR-based metabolomics reveals the metabolite profiles of Vibrio parahaemolyticus under ferric iron stimulation.
J Microbiol. 2017 Aug;55(8):628-634
Authors: Zhou J, Lu C, Zhang D, Ma C, Su X
Abstract
Vibrio parahaemolyticus is a halophilic bacterium endemic to coastal areas, and its pathogenicity has caused widespread seafood poisoning. In our previous research, the protein expression of V....
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07-29-2017 10:35 AM
[NMR paper] Systematic identification of protein-metabolite interactions in complex metabolite mixtures by ligand-detected NMR spectroscopy.
Systematic identification of protein-metabolite interactions in complex metabolite mixtures by ligand-detected NMR spectroscopy.
Systematic identification of protein-metabolite interactions in complex metabolite mixtures by ligand-detected NMR spectroscopy.
Biochemistry. 2016 Apr 11;
Authors: Nikolaev YV, Kochanowski K, Link H, Sauer U, Allain FH
Abstract
Protein-metabolite interactions play a vital role in the regulation of numerous cellular processes. Consequently, identifying such interactions is a key prerequisite for...
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04-12-2016 09:12 PM
[NMR paper] Biosynthesis of Drug Metabolites and Quantitation Using NMR Spectroscopy for use in Pharmacological and Drug Metabolism Studies.
Biosynthesis of Drug Metabolites and Quantitation Using NMR Spectroscopy for use in Pharmacological and Drug Metabolism Studies.
Biosynthesis of Drug Metabolites and Quantitation Using NMR Spectroscopy for use in Pharmacological and Drug Metabolism Studies.
Drug Metab Dispos. 2014 Jul 22;
Authors: Walker GS, Bauman JN, Ryder T, Smith EB, Spracklin DK, Obach RS
Abstract
The contribution of drug metabolites to the pharmacological and toxicological activity of a drug can be important; however, for a variety of reasons...
[Ryan's blog] NMR in the Movies? How to Secure a Date with Minnie Driver
Source: Ryan's blog
NMR in the Movies? How to Secure a Date with Minnie Driver
I was flying home from Europe yesterday and was watching the Oscar award-winning movie "Good Will Hunting" starring Matt Damon, Robin Williams, Ben Affleck, and Minnie Driver: One thing I missed the first time I saw the movie, was a...
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06-15-2012 02:10 PM
Nuclear magnetic resonance (NMR)-based drug metabolite profiling.
Nuclear magnetic resonance (NMR)-based drug metabolite profiling.
Nuclear magnetic resonance (NMR)-based drug metabolite profiling.
Methods Mol Biol. 2011;708:299-319
Authors: Lenz EM
The identification of drug metabolites in biofluids such as urine, plasma and bile is an important step in drug discovery and development. Proton nuclear magnetic resonance ((1)H-NMR) spectroscopy can provide detailed information regarding the structural transformation of a compound as a consequence of metabolism. However, successful identification of drug...
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04-09-2011 10:57 AM
Small molecules against Ebola: NMR reveals drug leads
Small molecules against Ebola: NMR reveals drug leads
There is neither vaccine nor cure for the Ebola virus, which causes fatal haemorrhagic fever in humans. However, a new NMR spectroscopic study by US researchers scientists has led to the discovery of a family of small molecules that apparently bind to the outer protein coat of the virus and halt its entry into human cells, so offering the possibility of an antiviral medication against the disease.
Source: Spectroscopynow.com
Date rape drug metabolite: NMR reveals evidence next day
Nuclear magnetic resonance (NMR) spectroscopy can be used to quickly identify a biomarker for the presence of gamma-hydroxybutyric acid (GHB, the so-called "date rape" drug) in a biological sample from a putative victim of crime. Details are reported in the American Chemical Society's journal Analytical Chemistry.
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