A structural model of the closed state of the "energy budget" enzyme adenylate kinase emerges from a nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography study by European scientists.
Flu clue: NMR spectroscopy and 1918
Flu clue: NMR spectroscopy and 1918
http://www.spectroscopynow.com/common/images/thumbnails/150148ef5a0.jpgNuclear magnetic resonance spectroscopy has led to new clues regarding the particularly virulent behaviour of the influenza virus that caused tens of millions of deaths at the end of World War I.
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10-01-2015 11:23 AM
[NMR paper] Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering.
Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering.
Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering.
Proc Natl Acad Sci U S A. 2015 Aug 24;
Authors: Venditti V, Schwieters CD, Grishaev A, Clore GM
Abstract
Enzyme I (EI) is the first component in the bacterial phosphotransferase system, a signal transduction pathway in which phosphoryl transfer through a series...
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08-26-2015 10:21 AM
NMR reveals cancer clue: p53 activity
NMR reveals cancer clue: p53 activity
http://www.spectroscopynow.com/common/images/thumbnails/14f25d494fb.jpgUS researchers have used NMR spectroscopy in a study of the activity of the tumour suppressor protein, p53. Their work reveals the mechanism by which p53 triggers programmed cell death (apoptosis) and may have implications for understanding the development of various forms of cancer and perhaps lead to new drug discoveries.
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08-15-2015 04:01 PM
Harnessing insulation: Magnetic clue
Harnessing insulation: Magnetic clue
http://www.spectroscopynow.com/common/images/thumbnails/14cb69ea9eb.jpgA subatomic magnetic phenomenon predicted more than sixty years ago has been measured for the first time. The demonstration of van Vleck magnetism could open the door to harnessing topological insulators - hybrid materials that are both conducting and insulating - and may well lead to new approaches to quantum computing, spintronics applications, and much-improved semiconductors.
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04-15-2015 04:40 PM
Alzheimer's disease: NMR pinpoints genetic clue
Alzheimer's disease: NMR pinpoints genetic clue
http://www.spectroscopynow.com/common/images/thumbnails/1438cadfde3.jpgResearchers have turned to solution NMR spectroscopy to help them characterise the structure and dynamics of the transmembrane portion of the protein amyloid precursor protein, APP, of which there are two genetic variants linked to familial, or hereditary Alzheimer's disease.
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01-15-2014 05:05 AM
Misbehaving Protein May Provide Clue to Alzheimer's Drug - Bloomberg
<img alt="" height="1" width="1" />
Misbehaving Protein May Provide Clue to Alzheimer's Drug
Bloomberg
Nuclear Imaging Tools Researchers used nuclear magnetic resonance imaging and computer modeling to see how proteins assemble themselves. Many of the intermediate states of folding last a millisecond or less, said Lewis Kay, a study author and a ...
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Misbehaving Protein May Provide Clue to Alzheimer's Drug - Bloomberg
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04-19-2012 07:35 PM
Spliced: NMR reveals structural clue to transcription
Spliced: NMR reveals structural clue to transcription
Biomolecular NMR experts in Germany have discovered how the U2AF protein facilitates the process of splicing used by cells to make the correct template for RNA transcription and the subsequent expression of proteins.
Source: Spectroscopynow.com
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08-01-2011 12:07 AM
[CNS Yahoo group] Summer X-rays at the NSLS
Summer X-rays at the NSLS
Summer X-rays at the NSLS The PXRR operates five beamlines at the NSLS: http://www.px.nsls.bnl.gov/. Two of these are the undulator beamlines X25 and X29. The
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Closed model: NMR and X-rays open up enzyme clue
A structural model of the closed state of the "energy budget" enzyme adenylate kinase emerges from a nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography study by European scientists.
Linear Mode
