NMR spectroscopists, X-ray crystallographers and their colleagues have taken an important step closer to understanding the molecular mechanism behind autoimmune diseases. They have solved the three-dimensional structure of the Roquin protein when it is bound to messenger RNA. The results revealed that there is a much wider range of functionally important Roquin binding partners than previously assumed.
Spaghetti virus: NMR clues to cancer-causing herpes
Spaghetti virus: NMR clues to cancer-causing herpes
http://www.spectroscopynow.com/common/images/thumbnails/1446d6b1158.jpgNMR spectroscopy research carried out at Manchester University has revealed that herpes virus proteins are more "spaghetti-like" than previously thought. The discovery hints at possible treatments for a form of the disease that causes the cancer known as Kaposi’s sarcoma.
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03-01-2014 11:11 AM
Plant dynamics: NMR offers cellular clues - spectroscopyNOW.com
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Plant dynamics: NMR offers cellular clues
spectroscopyNOW.com
Researchers in the USA have used dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy on what they describe as a super-sensitive instrument to locate precisely where a protein binds to plant cell walls, reveal a process that ...
Plant dynamics: NMR offers cellular clues - spectroscopyNOW.com
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10-01-2013 09:43 AM
Plant dynamics: NMR offers cellular clues
Plant dynamics: NMR offers cellular clues
http://www.spectroscopynow.com/common/images/thumbnails/14159dac51b.pngResearchers in the USA have used dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy on what they describe as a super-sensitive instrument to locate precisely where a protein binds to plant cell walls, reveal a process that loosens the cell walls and thus explains how plants can grow. The research might ultimately lead to more abundant biomass crop yields for renewable energy.
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10-01-2013 09:43 AM
DNA markers and disease: NMR and MS clues
DNA markers and disease: NMR and MS clues
http://www.spectroscopynow.com/common/images/thumbnails/13e459ee096.jpgResearchers have used NMR spectroscopy and mass spectrometry to help them understand the chemistry associated with modifications to DNA that are associated with autoimmune disease and cancer. The work offers new clues to the behaviour of modified bases and could open up avenues to new therapeutic agents.
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05-01-2013 11:46 AM
Alzheimer's analysed: New clues in brain disease
Alzheimer's analysed: New clues in brain disease
http://www.spectroscopynow.com/common/images/thumbnails/13af4d7f690.jpgRecent studies have added weight to the idea that amyloid-beta is a causative agent in Alzheimer's disease rather than the plaques formed from these chunks of misfolded peptide that deposit in the diseased brain. Now, European researchers have used REAPDOR solid-state NMR spectroscopy to analyse the hydrogen bonds in the tiny fibrils of amyloid-beta peptide, offering another perspective on this neurodegenerative disorder.
Source: Spectroscopynow.com
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02-03-2013 08:49 AM
Protein structures give disease clues - PhysOrg.com
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Protein structures give disease clues
PhysOrg.com
Credit: James Ames, UC Davis Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially ...
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Protein structures give disease clues - PhysOrg.com
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02-02-2012 09:43 PM
[NMR paper] NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insigh
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease.
Related Articles NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease.
J Biol Chem. 2005 Mar 25;280(12):11505-12
Authors: Bottomley MJ, Stier G, Pennacchini D, Legube G, Simon B, Akhtar A, Sattler M, Musco G
Mutations in the autoimmune regulator protein...
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11-24-2010 11:14 PM
[NMR paper] NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and
NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist: structural implications for the MHC II (I-Au)-peptide complex from docking calculations.
Related Articles NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist: structural implications for the MHC II (I-Au)-peptide complex from docking calculations.
Eur J Biochem. 2004 Aug;271(16):3399-413
Authors: Tzakos AG, Fuchs P, van Nuland NA, Troganis A, Tselios T, Deraos S, Matsoukas J, Gerothanassis IP, Bonvin AM
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Autoimmune mechanism: NMR and X-ray clues
NMR spectroscopists, X-ray crystallographers and their colleagues have taken an important step closer to understanding the molecular mechanism behind autoimmune diseases. They have solved the three-dimensional structure of the Roquin protein when it is bound to messenger RNA. The results revealed that there is a much wider range of functionally important Roquin binding partners than previously assumed.
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