Nuclear magnetic resonance (NMR) spectroscopy has been used to reveal for the first time the atom-by-atom changes that take place in a family of proteins associated with amyotrophic lateral sclerosis (ALS). This group of lethal brain disorders leads to frontotemporal dementia and degenerative diseases of muscle and bone.
Amyotrophic lateral sclerosis: NMR spots atomic changes - spectroscopyNOW.com
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Amyotrophic lateral sclerosis: NMR spots atomic changes
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Nuclear magnetic resonance (NMR) spectroscopy has been used to reveal for the first time the atom-by-atom changes that take place in a family of proteins associated with amyotrophic lateral sclerosis (ALS). This group of lethal brain disorders as well ...
Amyotrophic lateral sclerosis: NMR spots atomic changes -...
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02-01-2018 09:53 AM
Pick up a prion: Solid state NMR spots the differences
Pick up a prion: Solid state NMR spots the differences
http://www.spectroscopynow.com/common/images/thumbnails/15fb59fc93b.jpgResearchers in the USA have used solid-state nuclear magnetic resonance (NMR) spectroscopy to study the rogue proteins involved in familial human cerebral amyloid angiopathy (CAA). This hereditary neurodegenerative condition is one of the family of prion diseases that afflict mammals and include bovine spongiform encephalopathy (often referred to colloquially as "mad cow disease"), Creutzfeldt-Jakob disease in humans, their equivalents in cats, mice, hamsters and...
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11-15-2017 08:36 AM
NMR spots biosimilars: Filgrastim found
NMR spots biosimilars: Filgrastim found
http://www.spectroscopynow.com/common/images/thumbnails/152d0c5db04.jpgProtein NMR spectroscopy can be used to demonstrate the high similarity of the three dimensional structure between various product sources according to research published in the journal Nature Biotechnology.
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02-15-2016 12:28 PM
[NMR paper] Insights into SOD1-linked amyotrophic lateral sclerosis from NMR studies of Ni(2+)- and other metal-ion-substituted wild-type copper-zinc superoxide dismutases.
Insights into SOD1-linked amyotrophic lateral sclerosis from NMR studies of Ni(2+)- and other metal-ion-substituted wild-type copper-zinc superoxide dismutases.
Related Articles Insights into SOD1-linked amyotrophic lateral sclerosis from NMR studies of Ni(2+)- and other metal-ion-substituted wild-type copper-zinc superoxide dismutases.
J Biol Inorg Chem. 2014 Apr 2;
Authors: Ming LJ, Valentine JS
Abstract
The dimeric Cu-Zn superoxide dismutase (SOD1) is a particularly interesting system for biological inorganic chemical...
Constraining Binding Hot Spots: NMR and Molecular Dynamics Simulations Provide a Stru
Constraining Binding Hot Spots: NMR and Molecular Dynamics Simulations Provide a Structural Explanation for Enthalpy-Entropy Compensation in SH2-Ligand Binding.
Related Articles Constraining Binding Hot Spots: NMR and Molecular Dynamics Simulations Provide a Structural Explanation for Enthalpy-Entropy Compensation in SH2-Ligand Binding.
J Am Chem Soc. 2010 Aug 18;132(32):11058-70
Authors: Ward JM, Gorenstein NM, Tian J, Martin SF, Post CB
NMR spectroscopy and molecular dynamics (MD) simulations were used to probe the structure and dynamics...
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08-17-2010 03:36 AM
Constraining Binding Hot Spots: NMR and Molecular Dynamics Simulations Provide a Stru
Constraining Binding Hot Spots: NMR and Molecular Dynamics Simulations Provide a Structural Explanation for Enthalpy−Entropy Compensation in SH2−Ligand Binding
Joshua M. Ward<sup>†</sup>, Nina M. Gorenstein<sup>†</sup>, Jianhua Tian<sup>‡</sup>, Stephen F. Martin<sup>‡</sup> and Carol Beth Post*<sup>†</sup>
Department of Medicinal Chemistry, Markey Center for Structural Biology, and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, and Department of Chemistry and Biochemistry and The Institute of Cellular and Molecular Biology, The University of Texas,...
Amyotrophic lateral sclerosis: NMR spots atomic changes
Nuclear magnetic resonance (NMR) spectroscopy has been used to reveal for the first time the atom-by-atom changes that take place in a family of proteins associated with amyotrophic lateral sclerosis (ALS). This group of lethal brain disorders leads to frontotemporal dementia and degenerative diseases of muscle and bone.
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