Researchers have turned to solution NMR spectroscopy to help them characterise the structure and dynamics of the transmembrane portion of the protein amyloid precursor protein, APP, of which there are two genetic variants linked to familial, or hereditary Alzheimer's disease.
Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease - News-Medical.net
Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease - News-Medical.net
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Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease
News-Medical.net
Kai Schlepckow and Harald Schwalbe at the Goethe University Frankfurt am Main have successfully used time-resolved NMR spectroscopic studies to follow what is happening to every individual amino acid as the prion protein molecules aggregateâ??an ...
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08-16-2013 08:36 PM
Misbehaving Protein May Provide Clue to Alzheimer's Drug - Bloomberg
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Misbehaving Protein May Provide Clue to Alzheimer's Drug
Bloomberg
Nuclear Imaging Tools Researchers used nuclear magnetic resonance imaging and computer modeling to see how proteins assemble themselves. Many of the intermediate states of folding last a millisecond or less, said Lewis Kay, a study author and a ...
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Misbehaving Protein May Provide Clue to Alzheimer's Drug - Bloomberg
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04-19-2012 07:35 PM
Revealing Protein Structures in Solid-Phase Peptide Synthesis by 13C Solid-State NMR: Evidence of Excessive Misfolding for Alzheimer’s ?
Revealing Protein Structures in Solid-Phase Peptide Synthesis by 13C Solid-State NMR: Evidence of Excessive Misfolding for Alzheimer’s ?
Songlin Wang and Yoshitaka Ishii
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja212190z/aop/images/medium/ja-2011-12190z_0002.gif
Journal of the American Chemical Society
DOI: 10.1021/ja212190z
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/6EE7uthrnLg
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01-31-2012 08:34 PM
Spliced: NMR reveals structural clue to transcription
Spliced: NMR reveals structural clue to transcription
Biomolecular NMR experts in Germany have discovered how the U2AF protein facilitates the process of splicing used by cells to make the correct template for RNA transcription and the subsequent expression of proteins.
Source: Spectroscopynow.com
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08-01-2011 12:07 AM
Molecular-Level Examination of Cu2+ Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s ? by Solid-State NMR Spectroscopy
Molecular-Level Examination of Cu2+ Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s ? by Solid-State NMR Spectroscopy
Sudhakar Parthasarathy, Fei Long, Yifat Miller, Yiling Xiao, Dan McElheny, Kent Thurber, Buyong Ma, Ruth Nussinov and Yoshitaka Ishii
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja1072178/aop/images/medium/ja-2010-072178_0006.gif
Journal of the American Chemical Society
DOI: 10.1021/ja1072178
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA ...
[NMR paper] GANA--a genetic algorithm for NMR backbone resonance assignment.
GANA--a genetic algorithm for NMR backbone resonance assignment.
Related Articles GANA--a genetic algorithm for NMR backbone resonance assignment.
Nucleic Acids Res. 2005;33(14):4593-601
Authors: Lin HN, Wu KP, Chang JM, Sung TY, Hsu WL
NMR data from different experiments often contain errors; thus, automated backbone resonance assignment is a very challenging issue. In this paper, we present a method called GANA that uses a genetic algorithm to automatically perform backbone resonance assignment with a high degree of precision and recall....
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11-24-2010 11:14 PM
[NMR paper] Interaction of synthetic Alzheimer beta-protein-derived analogs with aqueous aluminum
Interaction of synthetic Alzheimer beta-protein-derived analogs with aqueous aluminum: a low-field 27Al NMR investigation.
Related Articles Interaction of synthetic Alzheimer beta-protein-derived analogs with aqueous aluminum: a low-field 27Al NMR investigation.
J Protein Chem. 1995 Nov;14(8):633-44
Authors: Vyas SB, Duffy LK
Synthetic peptides corresponding to the soluble Alzheimer beta-protein, i.e., beta 1-40 and beta 6-25, were utilized to investigate the association of aluminum using low-field 27Al nuclear magnetic resonance (NMR)...
Alzheimer's disease: NMR pinpoints genetic clue
Researchers have turned to solution NMR spectroscopy to help them characterise the structure and dynamics of the transmembrane portion of the protein amyloid precursor protein, APP, of which there are two genetic variants linked to familial, or hereditary Alzheimer's disease.
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