Thread: NMR paper NMR insights into beta-Lactamase activity of UVI31+ Protein from Chlamydomonas reinhardtii
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Default NMR insights into beta-Lactamase activity of UVI31+ Protein from Chlamydomonas reinhardtii
NMR insights into beta-Lactamase activity of UVI31+ Protein from Chlamydomonas reinhardtii

?-Lactamases (EC 3.5.2.6) confer resistance against ?-lactam group-containing antibiotics in bacteria and higher eukaryotes, including humans. Pathogenic bacterial resistance against ?-lactam antibiotics is a primary concern for potential therapeutic developments and drug targets. Here, we report putative ?-lactamase activity, sulbactam binding (a ?-lactam analogue) in the low ?M affinity range, and site-specific interaction studies of a 14 kDa UV- and dark-inducible protein (abbreviated as...

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