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NMR Techniques for Intrinsically Disordered Proteins (IDPs) - News-Medical.net
Jan 22, 2022 - 5:57 PM - by nmrlearner
nmrlearner's Avatar NMR Techniques for Intrinsically Disordered Proteins (IDPs) - News-Medical.net

NMR Techniques for Intrinsically Disordered Proteins (IDPs) News-Medical.net Read here
0 Replies | 7 Views
[NMR paper] Radio Signals from Live Cells: The Coming of Age of In-Cell Solution NMR
Jan 22, 2022 - 2:38 AM - by nmrlearner
nmrlearner's Avatar Radio Signals from Live Cells: The Coming of Age of In-Cell Solution NMR

A detailed knowledge of the complex processes that make cells and organisms alive is fundamental in order to understand diseases and to develop novel drugs and therapeutic treatments. To this aim, biological macromolecules should ideally be characterized at atomic resolution directly within the cellular environment. Among the existing structural techniques, solution NMR stands out as the only one able to investigate at high resolution the structure and dynamic behavior of macromolecules directly...

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0 Replies | 21 Views
[NMR paper] NMR Metabolomics Assessment of Osteogenic Differentiation of Adipose-Tissue-Derived Mesenchymal Stem Cells
Jan 22, 2022 - 2:38 AM - by nmrlearner
nmrlearner's Avatar NMR Metabolomics Assessment of Osteogenic Differentiation of Adipose-Tissue-Derived Mesenchymal Stem Cells

This Article presents, for the first time to our knowledge, an untargeted nuclear magnetic resonance (NMR) metabolomic characterization of the polar intracellular metabolic adaptations of human adipose-derived mesenchymal stem cells during osteogenic differentiation. The use of mesenchymal stem cells (MSCs) for bone regeneration is a promising alternative to conventional bone grafts, and untargeted metabolomics may unveil novel metabolic information on the osteogenic differentiation of MSCs,...

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0 Replies | 9 Views
[NMR paper] Atomic-resolution chemical characterization of (2x)72-kDa tryptophan synthase via four- and five-dimensional (1)H-detected solid-state NMR
Jan 22, 2022 - 2:38 AM - by nmrlearner
nmrlearner's Avatar Atomic-resolution chemical characterization of (2x)72-kDa tryptophan synthase via four- and five-dimensional (1)H-detected solid-state NMR

NMR chemical shifts provide detailed information on the chemical properties of molecules, thereby complementing structural data from techniques like X-ray crystallography and electron microscopy. Detailed analysis of protein NMR data, however, often hinges on comprehensive, site-specific assignment of backbone resonances, which becomes a bottleneck for molecular weights beyond 40 to 45 kDa. Here, we show that assignments for the (2x)72-kDa protein tryptophan synthase (665 amino acids per...

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0 Replies | 9 Views
[NMR paper] (77)Se-Enriched Selenoglycoside Enables Significant Enhancement in NMR Spectroscopic Monitoring of Glycan-Protein Interactions
Jan 22, 2022 - 2:38 AM - by nmrlearner
nmrlearner's Avatar (77)Se-Enriched Selenoglycoside Enables Significant Enhancement in NMR Spectroscopic Monitoring of Glycan-Protein Interactions

Detailed investigation of ligand-protein interactions is essential for better understanding of biological processes at the molecular level. Among these binding interactions, the recognition of glycans by lectins is of particular importance in several diseases, such as cancer; therefore, inhibition of glycan-lectin/galectin interactions represents a promising perspective towards developing therapeutics controlling cancer development. The recent introduction of ^(77)Se NMR spectroscopy for...

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0 Replies | 9 Views
[NMR paper] Presence of beta-Turn Structure in Recombinant Spider Silk Dissolved in Formic Acid Revealed with NMR
Jan 22, 2022 - 2:38 AM - by nmrlearner
nmrlearner's Avatar Presence of beta-Turn Structure in Recombinant Spider Silk Dissolved in Formic Acid Revealed with NMR

Spider dragline silk is a biopolymer with excellent mechanical properties. The development of recombinant spider silk protein (RSP)-based materials with these properties is desirable. Formic acid (FA) is a spinning solvent for regenerated Bombyx mori silk fiber with excellent mechanical properties. To use FA as a spinning solvent for RSP with the sequence of major ampullate spider silk protein from Araneus diadematus, we determined the conformation of RSP in FA using solution NMR to determine...

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[NMR paper] Synergies of Single Molecule Fluorescence and NMR for the Study of Intrinsically Disordered Proteins
Jan 22, 2022 - 2:38 AM - by nmrlearner
nmrlearner's Avatar Synergies of Single Molecule Fluorescence and NMR for the Study of Intrinsically Disordered Proteins

Single molecule fluorescence and nuclear magnetic resonance spectroscopy (NMR) are two very powerful techniques for the analysis of intrinsically disordered proteins (IDPs). Both techniques have individually made major contributions to deciphering the complex properties of IDPs and their interactions, and it has become evident that they can provide very complementary views on the distance-dynamics relationships of IDP systems. We now review the first approaches using both NMR and single molecule...

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0 Replies | 11 Views
[NMR paper] Investigation of lipolytic activity of the red king crab hepatopancreas homogenate by NMR spectroscopy
Jan 22, 2022 - 2:38 AM - by nmrlearner
nmrlearner's Avatar Investigation of lipolytic activity of the red king crab hepatopancreas homogenate by NMR spectroscopy

The digestive gland of craboids (hepatopancreas) is rich in a huge number of various enzymes (collagenases, nucleases, hyaluronidases, proteases), which are well studied at the moment. However, little is known about crustacean lipases. In this work, using H NMR spectroscopy, it was found that the hepatopancreas homogenate of the red king crab Paralithodes camtschaticus demonstrates high lipolytic activity against triacetin in a wide pH range and shows moderate activity against the...

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0 Replies | 9 Views
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