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Mutations linked to neurological disease enhance self-association of low-complexity protein sequences - Science
Jul 01, 2022 - 10:59 AM - by nmrlearner
nmrlearner's Avatar Mutations linked to neurological disease enhance self-association of low-complexity protein sequences Science
Mutations linked to neurological disease enhance self-association of low-complexity protein sequences - Science
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[NMR paper] Production and Preparation of Isotopically Labeled Human Membrane Proteins in Pichia pastoris for Fast-MAS-NMR Analyses
Jul 01, 2022 - 10:59 AM - by nmrlearner
nmrlearner's Avatar Production and Preparation of Isotopically Labeled Human Membrane Proteins in Pichia pastoris for Fast-MAS-NMR Analyses

Membrane proteins (MPs) comprise about one-third of the human proteome, playing critical roles in many physiological processes and associated disorders. Consistently, they represent one of the largest classes of targets for the pharmaceutical industry. Their study at the molecular level is however particularly challenging, resulting in a severe lack of structural and dynamic information that is hindering their detailed functional characterization and the identification of novel potent drug...

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[NMR paper] Solid-state NMR 13C and 15*N resonance assignments of Vibrio sp. SemiSWEET transporter in lipid bilayers
Jul 01, 2022 - 10:59 AM - by nmrlearner
nmrlearner's Avatar Solid-state NMR 13C and 15*N resonance assignments of Vibrio sp. SemiSWEET transporter in lipid bilayers

The Sugar Will Eventually be Exported Transporter (SWEET) family is a new class of transporters that plays crucial roles in the cellular sugar transport process. Their bacterial homologs, known as SemiSWEETs, are among the smallest transporters and can be used as a prototype for studying the biological properties of sugar transporters. Here, a set of dipolar-based multidimensional solid-state NMR spectra were employed to investigate the structure of Vibrio sp. SemiSWEET (Vs-SemiSWEET)...

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Huge Growth of Protein Trends and Technologies Market by 2029 | Rigaku Corporation (Japan), Hampton Research Corp. (US), Jena Bioscience GmbH (Germany) Designer Women - Designer Women
Jun 30, 2022 - 11:57 AM - by nmrlearner
nmrlearner's Avatar Huge Growth of Protein Trends and Technologies Market by 2029 | Rigaku Corporation (Japan), Hampton Research Corp. (US), Jena Bioscience GmbH (Germany) Designer Women Designer Women
Huge Growth of Protein Trends and Technologies Market by 2029 | Rigaku Corporation (Japan), Hampton Research Corp. (US), Jena Bioscience GmbH (Germany) Designer Women - Designer Women
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0 Replies | 11 Views
Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs | | SBU News - Stony Brook News
Jun 30, 2022 - 11:57 AM - by nmrlearner
nmrlearner's Avatar Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs | | SBU News Stony Brook News
Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs | | SBU News - Stony Brook News
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Protein Crystallization And Crystallography Market Size, Scope and Forecast | Bruker Corporation, Rigaku Corporation, Hampton Research, Agilent Technologies, Corning Incorporated, Tecan Group, SARomics Biostructures, Spectris plc, Charles River Labor
Jun 30, 2022 - 11:57 AM - by nmrlearner
nmrlearner's Avatar Protein Crystallization And Crystallography Market Size, Scope and Forecast | Bruker Corporation, Rigaku Corporation, Hampton Research, Agilent Technologies, Corning Incorporated, Tecan Group, SARomics Biostructures, Spectris plc, Charles River Labor - Designer Women

Protein Crystallization And Crystallography Market Size, Scope and Forecast | Bruker Corporation, Rigaku Corporation, Hampton Research, Agilent Technologies, Corning Incorporated, Tecan Group, SARomics Biostructures, Spectris plc, Charles River Labor Designer Women Read here
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[NMR paper] AlphaFold Models of Small Proteins Rival the Accuracy of Solution NMR Structures
Jun 30, 2022 - 11:57 AM - by nmrlearner
nmrlearner's Avatar AlphaFold Models of Small Proteins Rival the Accuracy of Solution NMR Structures

Recent advances in molecular modeling using deep learning have the potential to revolutionize the field of structural biology. In particular, AlphaFold has been observed to provide models of protein structures with accuracies rivaling medium-resolution X-ray crystal structures, and with excellent atomic coordinate matches to experimental protein NMR and cryo-electron microscopy structures. Here we assess the hypothesis that AlphaFold models of small, relatively rigid proteins have accuracies...

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[NMR paper] 19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase
Jun 29, 2022 - 5:34 AM - by nmrlearner
nmrlearner's Avatar 19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase

Understanding the structural arrangements of protein oligomers can support the design of ligands that interfere with their function in order to develop new therapeutic concepts for disease treatment. Recent crystallographic studies have elucidated a novel twisted and functionally inactive form of the homodimeric enzyme tRNA-guanine transglycosylase (TGT), a putative target in the fight against shigellosis. Active-site ligands have been identified that stimulate the rearrangement of one monomeric...

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