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Visualization of translation and protein biogenesis at the ER ... - Nature.com
Jan 29, 2023 - 7:06 PM - by nmrlearner
nmrlearner's Avatar Visualization of translation and protein biogenesis at the ER ... - Nature.com

Visualization of translation and protein biogenesis at the ER ... Nature.com Read here
0 Replies | 1 Views
Targeting protein phosphatases in cancer immunotherapy and ... - Nature.com
Jan 29, 2023 - 7:06 PM - by nmrlearner
nmrlearner's Avatar Targeting protein phosphatases in cancer immunotherapy and ... - Nature.com

Targeting protein phosphatases in cancer immunotherapy and ... Nature.com Read here
0 Replies | 1 Views
[NMR paper] Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR
Jan 29, 2023 - 7:06 PM - by nmrlearner
nmrlearner's Avatar Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR

Hepatitis B virus (HBV) capsid assembly modulators (CAMs) represent a recent class of anti-HBV antivirals. CAMs disturb proper nucleocapsid assembly, by inducing formation of either aberrant assemblies (CAM-A) or of apparently normal but genome-less empty capsids (CAM-E). Classical structural approaches have revealed the CAM binding sites on the capsid protein (Cp), but conformational information on the CAM-induced off-path aberrant assemblies is lacking. Here we show that solid-state NMR can...

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Design and characterization of a protein fold switching network - Nature.com
Jan 27, 2023 - 5:53 PM - by nmrlearner
nmrlearner's Avatar Design and characterization of a protein fold switching network - Nature.com

Design and characterization of a protein fold switching network Nature.com Read here
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Global 3D Protein Structure Analysis Market Report 2022-2032 ... - Yahoo Finance
Jan 27, 2023 - 5:53 PM - by nmrlearner
nmrlearner's Avatar Global 3D Protein Structure Analysis Market Report 2022-2032 ... - Yahoo Finance

Global 3D Protein Structure Analysis Market Report 2022-2032 ... Yahoo Finance Read here
0 Replies | 16 Views
[NMR paper] Solid-State NMR Characterization of Lyophilized Formulations of Monoclonal Antibody Therapeutics
Jan 27, 2023 - 5:53 PM - by nmrlearner
nmrlearner's Avatar Solid-State NMR Characterization of Lyophilized Formulations of Monoclonal Antibody Therapeutics

Monoclonal antibodies (mAbs) are an important and growing class of biotherapeutic drugs. Method development for the characterization of critical quality attributes, including higher-order structure (HOS), of mAbs remains an area of active inquiry. Recently, solution-state nuclear magnetic resonance (NMR) spectroscopy has received increased attention and is a means for reliable, high-resolution HOS characterization of aqueous-based preparations of mAbs. While mAbs are predominantly formulated in...

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[NMR paper] The effect of liquid-liquid extraction on metabolite detection and analysis using NMR spectroscopy in human synovial fluid
Jan 27, 2023 - 5:53 PM - by nmrlearner
nmrlearner's Avatar The effect of liquid-liquid extraction on metabolite detection and analysis using NMR spectroscopy in human synovial fluid

The evaluation of joint disease using synovial fluid is an emerging field of metabolic profiling. The analysis is challenged by multiple macromolecules which can obscure the small molecule chemistry. The use of protein precipitation and extraction has been evaluated previously, but not in synovial fluid. We systematically review the published NMR spectroscopy methods of synovial fluid analysis and investigated the efficacy of three different protein precipitation techniques: methanol,...

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[NMR paper] The Q163C/Q309C mutant of ?MI-domain is an active variant suitable for NMR characterization
Jan 27, 2023 - 5:53 PM - by nmrlearner
nmrlearner's Avatar The Q163C/Q309C mutant of ?MI-domain is an active variant suitable for NMR characterization

Integrin ?M?2 (Mac-1, CD11b/CD18, CR3) is an important adhesion receptor expressed on monocytes. Mac-1 is responsible for mediating cell migration, phagocytosis, degranulation as well as cell-cell fusion. It is also the most promiscuous integrin in terms of ligand specificity with over 100 ligands, most of which use the ?MI-domain as their binding site. Despite the importance of ?MI-domain in defining ligand interactions of Mac-1, structural studies of ?MI-domain's interactions with ligands are...

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