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[NMR paper] The highly flexible disordered regions of the SARS-CoV-2 nucleocapsid N protein within the 1-248 residue construct: sequence-specific resonance assignments through NMR
Mar 04, 2021 - 12:41 PM - by nmrlearner
nmrlearner's Avatar The highly flexible disordered regions of the SARS-CoV-2 nucleocapsid N protein within the 1-248 residue construct: sequence-specific resonance assignments through NMR

The nucleocapsid protein N from SARS-CoV-2 is one of the most highly expressed proteins by the virus and plays a number of important roles in the transcription and assembly of the virion within the infected host cell. It is expected to be characterized by a highly dynamic and heterogeneous structure as can be inferred by bioinformatics analyses as well as from the data available for the homologous protein from SARS-CoV. The two globular domains of the protein (NTD and CTD) have been investigated...

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[NMR paper] Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using (1)H NMR Spectroscopy
Mar 04, 2021 - 12:41 PM - by nmrlearner
nmrlearner's Avatar Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using (1)H NMR Spectroscopy

Biopharmaceutical proteins are important drug therapies in the treatment of a range of diseases. Proteins, such as antibodies (Abs) and peptides, are prone to chemical and physical degradation, particularly at the high concentrations currently sought for subcutaneous injections, and so formulation conditions, including buffers and excipients, must be optimized to minimize such instabilities. Therefore, both the protein and small molecule content of biopharmaceutical formulations and their...

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[NMR paper] NMR waterLOGSY as An Assay in Drug Development Programmes for Detecting Protein-Ligand Interactions-NMR waterLOGSY
Mar 04, 2021 - 12:41 PM - by nmrlearner
nmrlearner's Avatar NMR waterLOGSY as An Assay in Drug Development Programmes for Detecting Protein-Ligand Interactions-NMR waterLOGSY

In drug development programmes, multiple assays are needed for the determination of protein-compound interactions and evaluation of potential use in assays with protein-protein interactions. In this protocol we describe the waterLOGSY NMR method for confirming protein-ligand binding events.

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[NMR paper] Solid-State NMR of Membrane Proteins in Lipid Bilayers: To Spin or Not To Spin?
Mar 04, 2021 - 12:41 PM - by nmrlearner
nmrlearner's Avatar Solid-State NMR of Membrane Proteins in Lipid Bilayers: To Spin or Not To Spin?

ConspectusMembrane proteins mediate a plethora of cellular functions and represent important targets for drug development. Unlike soluble proteins, membrane proteins require native-like environments to fold correctly and be active. Therefore, modern structural biology techniques have aimed to determine the structure and dynamics of these membrane proteins at physiological temperature and in liquid crystalline lipid bilayers. With the flourishing of new NMR methodologies and improvements in...

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Researchers Target Nucleocapsid Protein to Combat COVID-19 - CU Anschutz Today
Mar 03, 2021 - 5:03 PM - by nmrlearner
nmrlearner's Avatar Researchers Target Nucleocapsid Protein to Combat COVID-19 - CU Anschutz Today

Researchers Target Nucleocapsid Protein to Combat COVID-19 CU Anschutz Today Read here
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Global Protein Crystallization & Crystallography Market Forecast Revised In A New Market Research Store Report As Covid-19 Projected To Hold A Massive Impact On Sales In 2020|Bruker Corporation (US), Rigaku Corporation (Japan), Hampton Research (
Mar 03, 2021 - 5:03 PM - by nmrlearner
nmrlearner's Avatar Global Protein Crystallization & Crystallography Market Forecast Revised In A New Market Research Store Report As Covid-19 Projected To Hold A Massive Impact On Sales In 2020|Bruker Corporation (US), Rigaku Corporation (Japan), Hampton Research (US) - NeighborWebSJ

Global Protein Crystallization & Crystallography Market Forecast Revised In A New Market Research Store Report As Covid-19 Projected To Hold A Massive Impact On Sales In 2020|Bruker Corporation (US), Rigaku Corporation (Japan), Hampton Research (US) NeighborWebSJ Read here
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[NMR paper] Covalent Probes for Aggregated Protein Imaging via Michael Addition
Mar 03, 2021 - 5:03 PM - by nmrlearner
nmrlearner's Avatar Covalent Probes for Aggregated Protein Imaging via Michael Addition


Angewandte Chemie International Edition, Accepted Article.

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